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Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
07 Feb 2022
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Research
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#neuroimaging
#epidural electrical stimulation
I am delighted to share our work published in Nature Medicine:
Nature Medicine, Vol. 28, pp. 260–271 (February 2022)
Andreas Rowald, Salif Komi, Robin Demesmaeker, Edeny Baaklini, Sergio Daniel Hernandez-Charpak, Edoardo Paoles, Hazael Montanaro, Antonino Cassara, Fabio Becce, Bryn Lloyd, Taylor Newton, Jimmy Ravier, Nawal Kinany, Marina D’Ercole, Aurélie Paley, Nicolas Hankov, Camille Varescon, Laura McCracken, Molywan Vat, Miroslav Caban, Anne Watrin, Charlotte Jacquet, Léa Bole-Feysot, Cathal Harte, Henri Lorach, Andrea Galvez, Manon Tschopp, Natacha Herrmann, Moïra Wacker, Lionel Geernaert, Isabelle Fodor, Valentin Radevich, Katrien Van Den Keybus, Grégoire Eberle, Etienne Pralong, Maxime Roulet, Jean-Baptiste Ledoux, Eleonora Fornari, Stefano Mandija, Loan Mattera, Roberto Martuzzi, Bruno Nazarian, Stefan Benkler, Simone Callegari, Nathan Greiner, Benjamin Fuhrer, Martijn Froeling, Nik Buse, Tim Denison, Rik Buschman, Christian Wende, Damien Ganty, Jurriaan Bakker, Vincent Delattre, Hendrik Lambert, Karen Minassian, Cornelis A. T. van den Berg, Anne Kavounoudias, Silvestro Micera, Dimitri Van De Ville, Quentin Barraud, Erkan Kurt, Niels Kuster, Esra Neufeld, Marco Capogrosso, Leonie Asboth, Fabien B. Wagner, Jocelyne Bloch, Grégoire Courtine
My contribution to this work focused on the development and application of a novel personalized lumbar spinal cord BOLD fMRI approach designed to map the segmental distribution of muscle innervation on an individual basis, using passive limb mobilization and muscle tendon mechanical vibration. I was also involved in constructing personalized models based on MRI and CT imaging of the spinal cord. These models were essential for conducting computational simulations to determine the optimal placement of EES implants for each participant.
Sergio Daniel Hernandez Charpak is a PhD Computational Scientist, a Physicist and Computing Engineer researching in the interface between AI / medical imaging in healthcare, and also an enthousiast of travel, hiking, chess and piano.